For the most popular RV campgrounds, the best time to book is usually as early as the park allows, especially for holiday weekends, school vacations, and any campground near a major national park, beach, or scenic destination. In many cases, that means setting a reminder for the first morning reservations open. Some parks take bookings 6 months out, some 12 months out, and a few premium private parks or state park systems have their own rules, so it pays to check the exact release date instead of guessing.
If you are aiming for a specific site type, like a pull-through big-rig spot, full hookups, waterfront sites, or a shaded pad close to the bathhouse, those tend to disappear first. The same goes for campgrounds with limited service or smaller site counts. If your travel dates are flexible, you will have a much better chance by targeting shoulder season instead of peak summer. Late spring and early fall often open up more options, and weekdays are usually easier than Fridays and Saturdays.
A good approach is to make your first reservation as soon as possible, even if it is not your ideal site, and then keep checking for cancellations. People change plans all the time. I have seen excellent sites open up a week or two before arrival, especially at parks with strict cancellation policies or weather-sensitive bookings. It also helps to join any campground notification system if they offer one, and to call the office directly once in a while instead of relying only on the online map. Some parks hold back a few sites for walk-ins, late releases, or same-day check-ins.
If you are booking around a holiday like Memorial Day, Fourth of July, Labor Day, or Thanksgiving, I would not wait at all. Those dates can be gone in minutes at the most sought-after campgrounds. For popular national and state parks, I would treat the reservation opening date like an event on the calendar and be ready a few minutes before it starts. Having your account set up, payment ready, and preferred sites picked in advance can make a real difference.
If you are traveling during a less busy time, you may still find good availability 1 to 3 months out, but the safest answer for popular RV campgrounds is: book as early as the system allows, then watch for cancellations if you want a better site later. That combination usually gives you the best shot without losing your place.